Article

Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/P38 signaling

2019-12-02

Abstract excerpt

<h4>ABSTRACT</h4> Benign peripheral nerve sheath tumors are the clinical hallmark of Neurofibromatosis Type 1. They account for substantial morbidity in NF1 and are difficult to manage. Cutaneous (CNF) and plexiform neurofibromas (PNF) share identical histology, but maintain different growth rates and risk of malignant conversion. The reasons for their disparate clinical behavior are not well explained on the bas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 076c6ecc-48cf-5a1e-b1cb-70a8678fe1f2
DOI: 10.1101/833467

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/P38 signalingDOI 10.1101/833467Read

Distinctive Epigenomic Alterations in NF1-deficient Cutaneous and Plexiform Neurofibromas Drive Differential MKK/p38 SignalingSemantic proximity Read

Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signalingSemantic proximity Read

Integrative analysis identifies candidate tumor microenvironment and intracellular signaling pathways that define tumor heterogeneity in NF1Semantic proximity Read

Cutaneous neurofibromas in the genomics era: current understanding and open questions.Semantic proximity Read

A Sequencing Overview of Malignant Peripheral Nerve Sheath Tumors: Findings and Implications for TreatmentSemantic proximity Read

Spatial Gene-Expression Profiling Unveils Immuno-oncogenic Programs of NF1-Associated Peripheral Nerve Sheath Tumor ProgressionSemantic proximity Read

Identification of potential common genetic modifiers of neurofibromas: a genome-wide association study in 1333 patients with neurofibromatosis type 1.Semantic proximity Read

Epigenetic Mechanisms in Neurofibromatosis Types 1 and 2Semantic proximity Read

Low mutation burden and frequent loss of CDKN2A/B and SMARCA2, but not PRC2, define premalignant neurofibromatosis type 1–associated atypical neurofibromasSemantic proximity Read

A detailed landscape of genomic alterations in malignant peripheral nerve sheath tumor cell lines challenges the current MPNST diagnosisSemantic proximity Read

From Genes to -Omics: The Evolving Molecular Landscape of Malignant Peripheral Nerve Sheath Tumor.Semantic proximity Read

Functional interactions between neurofibromatosis tumor suppressors drive Schwann cell tumor de-differentiation and treatment resistanceSemantic proximity Read