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A Proposed Link Between Acute Thymic Involution and Late Adverse Effects of Chemotherapy

1 Jul 2022

Abstract excerpt

Epidemiologic data suggest that cancer survivors tend to develop a protuberant number of adverse late effects, including second primary malignancies (SPM), as a result of cytotoxic chemotherapy. Besides the genotoxic potential of these drugs that directly inflict mutational burden on genomic DNA, the precise mechanisms contributing to SPM development are poorly understood. Cancer is nowadays perceived as a...

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PMID: 35844592
DOI: 10.3389/fimmu.2022.933547

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