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<i>Chlamydia trachomatis</i> modulates the expression of JAK-STAT signaling components to attenuate the Type II interferon response of epithelial cells

2024-01-10

Abstract excerpt

Chlamydia trachomatis has adapted to subvert signaling in epithelial cells to ensure successful intracellular development. Interferon-γ (IFNγ) produced by recruited lymphocytes signals through the JAK/STAT pathway to restrict chlamydial growth in the genital tract. However, during Chlamydia infection in vitro , addition of IFNγ does not fully induce nuclear localization of its transcription factor STAT1 and targ...

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Literature Corpus work
55607165-871d-53c6-98ce-e78da83c04de
DOI
10.1101/2024.01.09.574898
Open publication

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