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Cold-induced FOXO1 nuclear transport aids cold survival and tissue storage

3 Apr 2024

Abstract excerpt

Cold-induced injuries severely limit opportunities and outcomes of hypothermic therapies and organ preservation, calling for better understanding of cold adaptation. Here, by surveying cold-altered chromatin accessibility and integrated CUT&Tag/RNA-seq analyses in human stem cells, we reveal forkhead box O1 (FOXO1) as a key transcription factor for autonomous cold adaptation. Accordingly, we find a...

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PMID: 38570500
DOI: 10.1038/s41467-024-47095-w

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