Article

Several Mutations in the Melanocortin-4 Receptor Gene Including a Nonsense and a Frameshift Mutation Associated with Dominantly Inherited Obesity in Humans

1999-04-01

Abstract excerpt

The melanocortin-4 receptor gene (MC4-R) has been implicated in weight regulation. Recently, two independent groups reported frameshift mutations associated with a dominant form of obesity (1, 2). We screened the coding region of the MC4-R in 306 extremely obese children and adolescents (mean body mass index: BMI 34.4 ± 6.6 kg/m2), 25 healthy underweight students (mean BMI 17.1 ± 0.8 kg/m2), 52 normal weight indiv...

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Literature Corpus work: 54cfb194-5b22-50bb-8a3b-8fbd5f6623bb
DOI: 10.1210/jc.84.4.1483

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