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Microbiome impact of ibezapolstat and other <i>Clostridioides difficile</i> infection relevant antibiotics using humanized mice

2024-11-07

Abstract excerpt

<h4>Background</h4> Ibezapolstat (IBZ) is a competitive inhibitor of the bacterial Pol IIIC enzyme in clinical development for treatment of Clostridioides difficile infection (CDI). Previous studies demonstrated IBZ carries a favorable microbiome diversity profile compared to vancomycin (VAN). However, head-to-head comparisons with other CDI antibiotics have not been done. The purpose of this study was to compar...

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Literature Corpus work
54ad483e-859b-5eb8-9431-7a503f35091b
DOI
10.1101/2024.11.06.622322
Open publication

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