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Article

Establishment and molecular characterisation of patient-derived organoids for primary central nervous system lymphoma.

Leukemia - 1 May 2025

Li Shengjie, Ren Jun, Wu Jianing, Xia Zuguang, Li Yingzhu, Li Chengxun, Cao Wenjun

Abstract excerpt

Primary central nervous system lymphoma (PCNSL) exhibits substantial intratumoural and intertumoural heterogeneity, complicating the development of effective treatment methods. Existing in vitro models fail to simulate the cellular and mutational diversity of native tumours and require prolonged generation times. Therefore, we developed a culture method for patient-derived PCNSL organoids (CLOs) and evaluated the...

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PMID: 40102628
DOI: 10.1038/s41375-025-02562-1

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