Article

Angelic Acid Prevents RANKL-Induced Osteoclastogenesis Through Pathway-Biased Inhibition of MAPK–NFATc1 Signaling

2026-01-20

Abstract excerpt

<title>Abstract</title> <p> Excessive osteoclast activity drives inflammatory bone loss in osteoporosis, rheumatoid arthritis, and periodontitis. Natural compounds represent promising therapeutic candidates with favorable safety profiles; however, few exhibit pathway-biased mechanisms of action. Here, we report that angelic acid, a naturally occurring unsaturated monocarboxylic acid, potently inhibits RANKL-indu...

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Literature Corpus work: d5721051-4ae7-5b52-b07b-4e872d65bf43
DOI: 10.21203/rs.3.rs-8630319/v1

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