Article

Distinguishable DNA Methylation Defines a Cardiac-Specific Epigenetic Clock

2022-12-01

Abstract excerpt

BACKGROUND The present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic valvular replacement (AVR) or coronary artery bypass graft (CABG). An algorithm is also established to determine how the pathophysiological condition might influence the human biological cardiac age. RESULTS Blood samples and cardiac auricles were collected from patien...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 543cc05b-a9fd-598c-968a-8b2c8f781e5c
DOI: 10.21203/rs.3.rs-2317881/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinguishable DNA Methylation Defines a Cardiac-Specific Epigenetic ClockDOI 10.21203/rs.3.rs-2317881/v1Read

AI-driven biological clocks of cardiac aging: Should we integrate ECG, metabolomic, and epigenetic signatures?Semantic proximity Read

The epigenetic landscape of age-related diseases: the geroscience perspective.Semantic proximity Read

Cardiovascular health and four epigenetic clocksSemantic proximity Read

Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohortSemantic proximity Read

Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization studySemantic proximity Read

Deep learning-derived cardiovascular age shares a genetic basis with other cardiac phenotypesSemantic proximity Read

Deep learning-derived cardiovascular age shares a genetic basis with other cardiac phenotypes.Semantic proximity Read

Variational autoencoders to predict DNA-methylation age and provide biological insights in age-related health and diseaseSemantic proximity Read

AltumAge: A Pan-Tissue DNA-Methylation Epigenetic Clock Based on Deep LearningSemantic proximity Read

Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progressionSemantic proximity Read

An epigenetic clock for gestational age based on human umbilical vein endothelial cells from a diverse population of newbornsSemantic proximity Read

The association of accelerated epigenetic age with all-cause mortality in cardiac catheterization patients as mediated by vascular and cardiometabolic outcomesSemantic proximity Read