Article
The epigenetic landscape of age-related diseases: the geroscience perspective.
Biogerontology - 1 Aug 2017
Gensous Noémie, Bacalini Maria Giulia, Pirazzini Chiara, Marasco Elena, Giuliani Cristina, Ravaioli Francesco, Mengozzi Giacomo, Bertarelli Claudia, Palmas Maria Giustina, Franceschi Claudio, Garagnani Paolo
Abstract excerpt
In this review, we summarize current knowledge regarding the epigenetics of age-related diseases, focusing on those studies that have described DNA methylation landscape in cardio-vascular diseases, musculoskeletal function and frailty. We stress the importance of adopting the conceptual framework of "geroscience", which starts from the observation that advanced age is the major risk factor for several of these...
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