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Article

Impact of UGT1A1 genotype upon toxicities of combination with low-dose irinotecan plus platinum.

Asia-Pacific journal of clinical oncology - 1 Jun 2016

Takano Masashi, Yamamoto Kaichiro, Tabata Tsutomu, Minegishi Yuji, Yokoyama Takuma, Hirata Eiji, Ikeda Takeshi, Shimada Muneaki, Yamada Kouzo, Morita Satoshi, Ando Yuichi, Hirata Koji, Sugihara Masahiro, Sugiyama Toru, Ohashi Yasuo, Sakata Yuh

Abstract excerpt

AIM: Irinotecan-induced severe toxicities are possibly related to UGT1A1*6 and *28 genotypes. However, the correlation between UGT1A1 polymorphisms and the risk of toxicities induced by low-dose irinotecan plus platinum combination therapy still remains controversial. This prospective observational study aimed to examine the correlation between UGT1A1 genotypes and clinical outcomes of low-dose irinotecan (median...

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PMID: 26862009
DOI: 10.1111/ajco.12453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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