Article
Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Sept 2022
Soomro Mehreen, Stadler Michael, Dand Nick, Bluett James, Jadon Deepak, Jalali-Najafabadi Farideh, Duckworth Michael, Ho Pauline, Marzo-Ortega Helena, Helliwell Philip S, Ryan Anthony W, Kane David, Korendowych Eleanor, Simpson Michael A, Packham Jonathan, McManus Ross, Gabay Cem, Lamacchia Céline, Nissen Michael J, Brown Matthew A, Verstappen Suzanne M M, Van Staa Tjeerd, Barker Jonathan N, Smith Catherine H, FitzGerald Oliver, McHugh Neil, Warren Richard B, Bowes John, Barton Anne
Abstract excerpt
OBJECTIVES: Psoriatic arthritis (PsA) has a strong genetic component, and the identification of genetic risk factors could help identify the ~30% of psoriasis patients at high risk of developing PsA. Our objectives were to identify genetic risk factors and pathways that differentiate PsA from cutaneous-only psoriasis (PsC) and to evaluate the performance of PsA risk prediction models. METHODS: Genome-wide...
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