Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL.

doi:10.1038/jid.2011.415

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Article

Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL.

The Journal of investigative dermatology - 1 Apr 2012

Ellinghaus Eva, Stuart Philip E, Ellinghaus David, Nair Rajan P, Debrus Sophie, Raelson John V, Belouchi Majid, Tejasvi Trilokraj, Li Yanming, Tsoi Lam C, Onken Anna T, Esko Tonu, Metspalu Andres, Rahman Proton, Gladman Dafna D, Bowcock Anne M, Helms Cynthia, Krueger Gerald G, Koks Sulev, Kingo Külli, Gieger Christian, Wichmann H Erich, Mrowietz Ulrich, Weidinger Stephan, Schreiber Stefan, Abecasis Gonçalo R, Elder James T, Weichenthal Michael, Franke Andre

Abstract excerpt

Psoriatic arthritis (PsA) is a chronic inflammatory musculoskeletal disease affecting up to 30% of psoriasis vulgaris (PsV) cases and approximately 0.25 to 1% of the general population. To identify common susceptibility loci, we performed a meta-analysis of three imputed genome-wide association studies (GWAS) on psoriasis, stratified for PsA. A total of 1,160,703 single-nucleotide polymorphisms (SNPs) were...

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Identifiers

PMID: 22170493
DOI: 10.1038/jid.2011.415
PMCID: PMC3305829

Genes

REL
TNFAIP3
TNIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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