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Article

Gestational exposure to chlordecone promotes transgenerational changes in the murine reproductive system of males

2 Jul 2018

Abstract excerpt

Environmental factors can affect epigenetic events during germline reprogramming and impose distinctive transgenerational consequences onto the offspring. In this study, we examined the transgenerational effects of chlordecone (CD), an organochlorine insecticide with well-known estrogenic properties. We exposed pregnant mice to CD from embryonic day 6.5 to 15.5 and observed a reduction in spermatogonia (SG)...

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PMID: 29980752
DOI: 10.1038/s41598-018-28670-w

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