Article

Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells

2022-03-20

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a global economic and health crisis. Recently, plasma levels of galectin-9 (Gal-9), a β-galactoside-binding lectin involved in immune regulation and viral immunopathogenesis, were reported to be elevated in the setting of severe COVID-19 disease. However, the impact of Gal-9 on SARS-CoV-2 infection and immunopathology remained to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 53d5f199-eb40-5aac-989a-84c8488f0550
DOI: 10.1101/2022.03.18.484956

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial CellsDOI 10.1101/2022.03.18.484956Read

Epithelial galectin-3 induces mitochondrial complex inhibition and cell cycle arrest of CD8 <sup>+</sup> T Cells in severe/critical ill COVID-19Semantic proximity Read

Insights into standards of care – dexamethasone and antibodies against COVID-19 in hamster modelsSemantic proximity Read

Distinct Mucoinflammatory Phenotype and the Immunomodulatory Long Noncoding Transcripts Associated with SARS-CoV-2 Airway InfectionSemantic proximity Read

Human Galectin-9 Is a Potent Mediator of HIV Transcription and ReactivationSemantic proximity Read

Galectin-3 as a modifier of anti-microbial immunity: Unraveling the unknownsSemantic proximity Read

Human Surfactant Protein A Alleviates SARS-CoV-2 Infectivity in Human Lung Epithelial CellsSemantic proximity Read

A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivoSemantic proximity Read

Scrutiny of human lung infection by SARS-CoV-2 and associated human immune responses in humanized miceSemantic proximity Read

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studiesSemantic proximity Read

Galectin-9: From cell biology to complex disease dynamicsSemantic proximity Read

A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivoSemantic proximity Read

Paracrinal Regulation of Neutrophil Functions by Coronaviral Infection in Ipsc-Derived Alveolar Type Ii Epithelial CellsSemantic proximity Read