Article

Epithelial galectin-3 induces mitochondrial complex inhibition and cell cycle arrest of CD8 <sup>+</sup> T Cells in severe/critical ill COVID-19

2023-03-15

Abstract excerpt

Several studies have identified the presence of functionally depleted CD8 + T cells in COVID-19 patients, and particularly abnormally reduced CD8 + T cells in severe/critical patients, which may be a major cause of disease progression and poor prognosis. In this study, a proliferating-depleted CD8 + T cell phenotype was observed in severe/critical COVID-19 patients through scRNA-seq and scTCR-seq analysis. Thes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 115885cf-62ec-5cbc-bdb7-039fd066dfeb
DOI: 10.1101/2023.03.14.532609

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epithelial galectin-3 induces mitochondrial complex inhibition and cell cycle arrest of CD8 <sup>+</sup> T Cells in severe/critical ill COVID-19DOI 10.1101/2023.03.14.532609Read

Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individualsSemantic proximity Read

Expansion of Cytotoxic CD4+ T cells in the lungs in severe COVID-19Semantic proximity Read

CD8 T cells compensate for impaired humoral immunity in COVID-19 patients with hematologic cancerSemantic proximity Read

Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA SequencingSemantic proximity Read

Regulatory T-cells are central hubs for age-, sex- and severity-associated cellular networks during COVID-19Semantic proximity Read

Immune checkpoint dysregulation in COVID-19 pathogenesis and disease severity.Semantic proximity Read

Inhibitory immune checkpoint molecules and exhaustion of T cells in COVID-19.Semantic proximity Read

Immune targeted therapies for COVID-19 Infection: A Promising OutlookSemantic proximity Read

Comparative evaluation of memory T cells in COVID-19 patients and the predictive role of CD4+CD8+ double positive T lymphocytes as a new markerSemantic proximity Read

ScRNA-Seq Reveals T Cell Immunity in COVID-19 Patients and Implications for ImmunotherapySemantic proximity Read

Expansion of Cytotoxic CD4+ T Cells in the Lungs in Severe COVID-19Semantic proximity Read

Patients with moderate to severe COVID-19 have an impaired cytokine response with an exhausted and senescent immune phenotype.Semantic proximity Read