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Article

Pan-Trk Immunohistochemistry Identifies NTRK Rearrangements in Pediatric Mesenchymal Tumors.

The American journal of surgical pathology - 1 Jul 2018

Rudzinski Erin R, Lockwood Christina M, Stohr Bradley A, Vargas Sara O, Sheridan Rachel, Black Jennifer O, Rajaram Veena, Laetsch Theodore W, Davis Jessica L

Abstract excerpt

Activating neurotrophic receptor kinase (NTRK) fusions define certain pediatric mesenchymal tumors, including infantile fibrosarcoma and cellular mesoblastic nephroma. Traditionally, molecular confirmation of these fusions has included either fluorescent in situ hybridization for ETV6 rearrangements or reverse-transcriptase polymerase chain reaction for the classic ETV6-NTRK3 fusion. However, these methods...

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Share to Fibrosarcoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Membrane Glycoproteins

Share to Receptor, trkA

Share to Receptor, trkB

Share to Receptor, trkC

Share to Receptors, Nerve Growth Factor

Source

Identifiers

PMID: 29683818
DOI: 10.1097/PAS.0000000000001062

Genes

ETV6
NTRK3
NTRK1
NTRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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