Article

Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecoviruses

2022-01-26

Abstract excerpt

As the SARS-CoV-2 pandemic enters its third year, vaccines that not only prevent disease, but also prevent transmission are needed to help reduce global disease burden. Currently approved parenteral vaccines induce robust systemic immunity, but poor immunity at the respiratory mucosa. Here we describe the development of a novel vaccine strategy, Prime and Spike, based on unadjuvanted intranasal spike boosting that...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 52b9fd7c-1f62-5231-ad3d-bf1c82a4554b
DOI: 10.1101/2022.01.24.477597

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecovirusesDOI 10.1101/2022.01.24.477597Read

Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccinationSemantic proximity Read

Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccinationSemantic proximity Read

Single-dose respiratory mucosal delivery of next-generation viral-vectored COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2Semantic proximity Read

A Single Chimeric Spike Antigen Induces Pan-Sarbecovirus ImmunitySemantic proximity Read

An intranasal vaccine durably protects against SARS-CoV-2 variants in miceSemantic proximity Read

Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaquesSemantic proximity Read

UB-612, a Multitope Universal Vaccine Eliciting a Balanced B and T Cell Immunity against SARS-CoV-2 Variants of ConcernSemantic proximity Read

Prime-pull immunization of mice with a BcfA-adjuvanted vaccine elicits mucosal immunity and prevents SARS CoV-2 infection and pathologySemantic proximity Read

A Single Dose of COVID-19 mRNA Vaccine Induces Airway Immunity in COVID-19 Convalescent PatientsSemantic proximity Read

Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2Semantic proximity Read

One mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2Semantic proximity Read

An intranasal OMV-based vaccine induces high mucosal and systemic protecting immunity against a SARS-CoV-2 infectionSemantic proximity Read