Article

Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination

2023-01-25

Abstract excerpt

<h4>ABSTRACT</h4> Respiratory mucosal immunity induced by vaccination is vital for protection from coronavirus infection in animal models. In humans, SARS-CoV-2 immunity has been studied extensively in blood. However, the capacity of peripheral vaccination to generate sustained humoral and cellular immunity in the lung mucosa, and how this is influenced by prior SARS-CoV-2 infection, is unknown. Bronchoalveolar l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 83b49741-3184-56f4-bc6d-3db9e4495e60
DOI: 10.1101/2023.01.25.525485

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccinationDOI 10.1101/2023.01.25.525485Read

Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccinationSemantic proximity Read

Mechanisms of superior respiratory IgA responses against SARS-CoV-2 after mucosal vaccinationSemantic proximity Read

Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunitySemantic proximity Read

Airway-resident functional T cell responses against SARS-CoV-2 in unexposed individualsSemantic proximity Read

Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecovirusesSemantic proximity Read

Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in miceSemantic proximity Read

Imprinted SARS-CoV-2-Specific Memory Lymphocytes Define Hybrid ImmunitySemantic proximity Read

T Cell Immune Responses to SARS-CoV-2 Infection and VaccinationSemantic proximity Read

Phase 1 Study of Safety, Reactogenicity, and Immunogenicity of a Novel MVA-SARS-2-ST Vaccine Candidate Administered as Inhalation Boost in SARS-CoV-2 Immunized AdultsSemantic proximity Read

Mucosal and systemic responses to SARS-CoV-2 vaccination in infection naïve and experienced individualsSemantic proximity Read

Mucosal vaccination for SARS-CoV-2 elicits superior systemic T central memory function and cross-neutralizing antibodies against variants of concernSemantic proximity Read

SARS-CoV-2-Specific CD8<sup>+</sup> T Cells in Blood but Not in the Lungs of Vaccinated K18-hACE2 Mice after InfectionSemantic proximity Read