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Article

Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

8 Feb 2022

Abstract excerpt

The emerging SARS-CoV-2 variants of concern (VOCs) threaten the effectiveness of current COVID-19 vaccines administered intramuscularly and designed to only target the spike protein. There is a pressing need to develop next-generation vaccine strategies for broader and long-lasting protection. Using adenoviral vectors (Ad) of human and chimpanzee origin, we evaluated Ad-vectored trivalent COVID-19 vaccines...

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PMID: 35180381
DOI: 10.1016/j.cell.2022.02.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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