The role of Trp-82 in the folding of intestinal fatty acid binding protein.

doi:10.1002/prot.20463

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Article

The role of Trp-82 in the folding of intestinal fatty acid binding protein.

Proteins - 1 Oct 2005

Dalessio Paula M, Fromholt Susan E, Ropson Ira J

Abstract excerpt

Multiple phases have been observed during the folding and unfolding of intestinal fatty acid binding protein (WT-IFABP) by stopped-flow fluorescence. Site-directed mutagenesis has been used to examine the role of each of the two tryptophans of this protein in these processes. The unfolding and refolding kinetics of the mutant protein containing only tryptophan 82 (W6Y-IFABP) showed that the tryptophan at this...

Topics

Circular Dichroism
Fatty Acid-Binding Proteins
Kinetics
Models, Molecular
Mutation
Protein Denaturation
Protein Folding
Protein Structure, Tertiary
Spectrometry, Fluorescence
Thermodynamics
Tryptophan
Urea

Source

Open in PubMed

Identifiers

PMID: 16080148
DOI: 10.1002/prot.20463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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