Article

NOD2 modulates MDA5 signaling to promote coxsackievirus B3 replication

2025-05-10

Abstract excerpt

Coxsackievirus is an enteric virus that encounters intestinal epithelial cells (IECs) after ingestion and can cause a range of illnesses from mild to severe, including gastroenteritis, pancreatitis, central nervous system diseases and myocarditis. Sensing of CVB3 RNA by melanoma differentiation-associated gene (MDA5) induces a Type 1 Interferon (T1IFN) response that is critical for reducing viral replication and d...

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Literature Corpus work: 5288475c-d695-5862-bef7-c122da83726f
DOI: 10.1101/2025.05.06.652463

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