Article
NOD2 (Nucleotide-Binding Oligomerization Domain 2) Is a Major Pathogenic Mediator of Coxsackievirus B3-Induced Myocarditis.
Circulation. Heart failure - 1 Sept 2017
Tschöpe Carsten, Müller Irene, Xia Yu, Savvatis Konstantinos, Pappritz Kathleen, Pinkert Sandra, Lassner Dirk, Heimesaat Markus M, Spillmann Frank, Miteva Kapka, Bereswill Stefan, Schultheiss Heinz-Peter, Fechner Henry, Pieske Burkert, Kühl Uwe, Van Linthout Sophie
Abstract excerpt
BACKGROUND: The cytoplasmatic pattern recognition receptor, NOD2 (nucleotide-binding oligomerization domain 2), belongs to the innate immune system and is among others responsible for the recognition of single-stranded RNA. With Coxsackievirus B3 (CVB3) being a single-stranded RNA virus, and the recent evidence that the NOD2 target, NLRP3 (NOD-like receptor family, pyrin domain containing 3) is of importance in...
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