Article

MTDH-SND1 disruption sensitizes ovarian cancer to ferroptosis and PARP inhibition

2026-05-20

Abstract excerpt

BRCA-deficient high-grade serous ovarian cancer is characterized by profound genomic instability and elevated replication-associated DNA damage, rendering these tumors initially sensitive to platinum-based chemotherapy and PARP inhibition. However, despite this vulnerability, most patients ultimately develop resistance, underscoring the need for therapeutic strategies that extend beyond DNA repair–targeted mechani...

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Literature Corpus work: 526edbed-f89d-5735-beed-3198b6893f37
DOI: 10.64898/2026.05.18.725896

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