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The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies

14 Mar 2023

Abstract excerpt

Prior research establishing that bone interacts in coordination with the bone marrow microenvironment (BMME) to regulate hematopoietic homeostasis was largely based on analyses of individual bone-associated cell populations. Recent advances in intravital imaging has suggested that the expansion of hematopoietic stem cells (HSCs) and acute myeloid leukemia cells is restricted to bone marrow microdomains during a...

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PMID: 36918531
DOI: 10.1038/s41413-023-00249-w

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