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A FRET-based high-throughput screening assay for the discovery of <i>Mycobacterium tuberculosis</i> DNA ADP-ribosylglycohydrolase DarG inhibitors

2025-07-05

Abstract excerpt

DarTG2 is a conserved toxin-antitoxin ADP-ribosylation system that regulates bacterial survival and the anti-phage response found in many pathogenic bacteria, including Mycobacterium tuberculosis . While DNA ADP-ribosyltransferase (DarT2) toxin mono-ADP-ribosylates a single-stranded DNA sequence motif and potentially induces bacterial dormancy, its cognate DNA ADP-ribosylglycohydrolase (DarG) antitoxin reverses t...

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Literature Corpus work
520304dc-4124-5615-9fac-881989ae997a
DOI
10.1101/2025.07.02.662713
Open publication

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A FRET-based high-throughput screening assay for the discovery of <i>Mycobacterium tuberculosis</i> DNA ADP-ribosylglycohydrolase DarG inhibitorsDOI 10.1101/2025.07.02.662713
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