Article
Aptamer-mediated inhibition of Mycobacterium tuberculosis polyphosphate kinase 2.
Biochemistry - 19 Apr 2011
Shum Ka To, Lui Eric Lik Hang, Wong Sybil Cheuk Ki, Yeung Pok, Sam Laiju, Wang Ying, Watt Rory M, Tanner Julian A
Abstract excerpt
Inorganic polyphosphate (polyP) plays a number of critical roles in bacterial persistence, stress, and virulence. PolyP intracellular metabolism is regulated by the polyphosphate kinase (PPK) protein families, and inhibition of PPK activity is a potential approach to disrupting polyP-dependent processes in pathogenic organisms. Here, we biochemically characterized Mycobacterium tuberculosis (MTB) PPK2 and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.