Article

Monitoring Drug-Target Interactions through Target Engagement-Mediated Amplification on Arrays and in situ

2021-12-06

Abstract excerpt

<title>Abstract</title> <p>Drugs are designed to bind their target proteins in physiologically relevant tissues and organs to modulate biological functions and elicit desirable clinical outcomes. Information about target engagement at cellular and subcellular resolution is therefore critical for guiding compound optimization in drug discovery, and for probing resistance mechanisms to targeted therapies in clinica...

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Literature Corpus work: 51950d83-25e1-5fd8-9780-0b61bb00ffd7
DOI: 10.21203/rs.3.rs-1109577/v1

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