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Article

Annotation of human cancers with EGFR signaling–associated protein complexes using proximity ligation assays

13 Jan 2015

Abstract excerpt

Strategies to measure functional signaling-associated protein complexes have the potential to augment current molecular biomarker assays, such as genotyping and expression profiling, used to annotate diseases. Aberrant activation of epidermal growth factor receptor (EGFR) signaling contributes to diverse cancers. We used a proximity ligation assay (PLA) to detect EGFR in a complex with growth factor...

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PMID: 25587191
DOI: 10.1126/scisignal.2005906

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