Article

Glucocorticoid and Mineralocorticoid Receptors Jointly Promote Vascular Development in Kidney Organoids

2025-09-04

Abstract excerpt

<h4>Summary</h4> To examine the co-development of vasculature and renal epithelial tissue, we employed a human pluripotent stem cell-derived kidney organoid system. We found that cooperative signaling through the glucocorticoid receptor and mineralocorticoid receptor via hydrocortisone enabled rich endothelial cell differentiation and vessel formation. Bulk RNA sequencing analysis revealed that hydrocortisone per...

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Literature Corpus work: 515cba09-59b2-5855-a6be-a29ff5ebc7c1
DOI: 10.1101/2025.09.03.673963

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