Article

Stochastic inference of clonal dominance in gene therapy studies

2022-05-31

Abstract excerpt

Clonal dominance is a wake-up-call for adverse events in gene therapy applications. This phenomenon has mainly been observed as a consequence of a malignancy progression, and, in some rare cases, also during normal haematopoiesis. We propose here a random-effects stochastic model that allows for a quick detection of clonal expansions that possibly occur during a gene therapy treatment. Starting from the Ito-type e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 50efdc43-19b1-5b45-9edc-d8658c24b1eb
DOI: 10.1101/2022.05.31.494100

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stochastic inference of clonal dominance in gene therapy studiesDOI 10.1101/2022.05.31.494100Read

<i>barcodetrackR</i> : an R package for the interrogation of clonal tracking dataSemantic proximity Read

Heritable tumor cell division rate heterogeneity induces clonal dominance.Semantic proximity Read

Long-term tracking of haematopoietic clonal dynamics and mutations in non-human primate undergoing transplantation of lentivirally barcoded haematopoietic stem and progenitor cells.Semantic proximity Read

BESTish: A Diffusion-Approximation Framework for Inferring Selection and Mutation in Clonal HematopoiesisSemantic proximity Read

RAISING: a high-performance method for identifying random transgene integration sitesSemantic proximity Read

Impact of Resistance on Therapeutic Design: A Moran Model of Cancer GrowthSemantic proximity Read

Mechanisms of blood homeostasis: lineage tracking and a neutral model of cell populations in rhesus macaqueSemantic proximity Read

A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues.Semantic proximity Read

Preventing clonal evolutionary processes in cancer: Insights from mathematical models.Semantic proximity Read

Evaluation of diversity indices to estimate clonal dominance in gene therapy studiesSemantic proximity Read

Modelling the diversity and persistence of the human T-lymphotropic virus type-1Semantic proximity Read

Clonal Diversity at Early Cancer Recurrence.Semantic proximity Read