Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of diversity indices to estimate clonal dominance in gene therapy studies

9 May 2023

Abstract excerpt

In cell and gene therapy, achieving the stable engraftment of an abundant and highly polyclonal population of gene-corrected cells is one of the key factors to ensure the successful and safe treatment of patients. Because integrative vectors have been associated with possible risks of insertional mutagenesis leading to clonal dominance, monitoring the relative abundance of individual vector insertion sites in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to SARS-CoV-2 and COVID-19 Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37251980
DOI: 10.1016/j.omtm.2023.05.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of diversity indices to estimate clonal dominance in gene therapy studiesPMID 37251980Read ↗

Inference with viral quasispecies diversity indices: clonal and NGS approaches.Semantic proximity Read ↗

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.Semantic proximity Read ↗

Profiling cytogenetic diversity with entropy-based karyotypic analysis.Semantic proximity Read ↗

T Cell Clonal Dynamics Determined by High-Resolution TCR-β Sequencing in Recipients after Allogeneic Hematopoietic Cell TransplantationSemantic proximity Read ↗

Stochastic inference of clonal dominance in gene therapy studiesSemantic proximity Read ↗

Modelling the diversity and persistence of the human T-lymphotropic virus type-1Semantic proximity Read ↗

Measurement of biological information with applications from genes to landscapes.Semantic proximity Read ↗

Exploring the impact of clonal definition on B-cell diversity: implications for the analysis of immune repertoiresSemantic proximity Read ↗

Methods for diversity and overlap analysis in T-cell receptor populations.Semantic proximity Read ↗

Mechanisms of blood homeostasis: lineage tracking and a neutral model of cell populations in rhesus macaqueSemantic proximity Read ↗

Quantifying B-cell Clonal Diversity In Repertoire DataSemantic proximity Read ↗

Stem cell graft dose and composition could impact on the expansion of donor-derived clones after allogeneic hematopoietic stem cell transplantation - a virtual clinical trial.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.