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Article

Microfluidic device for primary tumor spheroid isolation

7 Aug 2017

Abstract excerpt

BACKGROUND: Traditional two-dimensional (2-D) monolayer cell culture is vastly different from in vivo physiological conditions, which can lead to inaccurate or insufficient data in areas where response and efficacy within humans are being investigated, such as drug discovery, pathology studies, etc. Misleading results arise from two main disadvantages of monolayer cell culture. First, after several passages, cell...

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PMID: 28794917
DOI: 10.1186/s40164-017-0084-3

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