Article

Multi-Objective Active Learning Overcomes Liver Tropism in LNP- Mediated mRNA Delivery to the Brain

2026-07-21

Abstract excerpt

<title>Abstract</title> <p> Lipid nanoparticles (LNPs) are the leading platform for mRNA delivery, yet their intrinsic liver tropism—driven by endogenous apolipoprotein E (ApoE) adsorption and hepatic LDL-receptor uptake—largely excludes them from the central nervous system (CNS). Functionalizing LNPs with ApoE-mimetic peptides to engage receptor-mediated transcytosis is a biologically grounded strategy, but the...

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Literature Corpus work: 506eb3e0-65c1-5483-8532-94af33ce64d3
DOI: 10.21203/rs.3.rs-10380055/v1

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