Article

How structural elements added by evolution from bacterial transporters to human SLC6 homologs have enabled new functional properties

2017-10-16

Abstract excerpt

Much of the structure-based mechanistic understandings of the function of SLC6A neurotransmitter transporters emerged from the study of their bacterial LeuT-fold homologs. It has become evident, however, that structural differences such as the long N- and C-termini of the eukaryotic neurotransmitter transporters impart an expanded set of functional properties to the eukaryotic transporters, which are not shared by...

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Literature Corpus work: 5055eecf-cb5b-5c8e-8e17-2891db72db8b
DOI: 10.1101/204164

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