Article
The aromatase gene CYP19A1: several genetic and functional lines of evidence supporting a role in reading, speech and language.
Behavior genetics - 1 Jul 2012
Anthoni Heidi, Sucheston Lara E, Lewis Barbara A, Tapia-Páez Isabel, Fan Xiaotang, Zucchelli Marco, Taipale Mikko, Stein Catherine M, Hokkanen Marie-Estelle, Castrén Eero, Pennington Bruce F, Smith Shelley D, Olson Richard K, Tomblin J Bruce, Schulte-Körne Gerd, Nöthen Markus, Schumacher Johannes, Müller-Myhsok Bertram, Hoffmann Per, Gilger Jeffrey W, Hynd George W, Nopola-Hemmi Jaana, Leppanen Paavo H T, Lyytinen Heikki, Schoumans Jacqueline, Nordenskjöld Magnus, Spencer Jason, Stanic Davor, Boon Wah Chin, Simpson Evan, Mäkelä Sari, Gustafsson Jan-Åke, Peyrard-Janvid Myriam, Iyengar Sudha, Kere Juha
Abstract excerpt
Inspired by the localization, on 15q21.2 of the CYP19A1 gene in the linkage region of speech and language disorders, and a rare translocation in a dyslexic individual that was brought to our attention, we conducted a series of studies on the properties of CYP19A1 as a candidate gene for dyslexia and related conditions. The aromatase enzyme is a member of the cytochrome P450 super family, and it serves several key...
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