Article

Metabolic and Thermal Cues Shape IL-6 Response and Disease Tolerance Mechanisms in Severe Malaria

2026-04-16

Abstract excerpt

Severe malaria disproportionately affects children during their earliest Plasmodium falciparum infections, when immunopathology rather than parasite burden often drives clinical deterioration. Because direct investigation of host-parasite interactions during severe disease is ethically impossible, we developed a two-dimensional ex vivo co-culture system that recapitulates key physiological features of malaria path...

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Literature Corpus work: 4fddaaf1-cdaa-58be-9211-11b2440b0854
DOI: 10.64898/2026.04.14.718305

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