Article

Metabolomic-driven prediction of the mutational status of healthy individuals with a family history of hereditary breast and ovarian cancer syndrome: The HRRmet study

2025-09-01

Abstract excerpt

<title>Abstract</title> <p> Pathogenic variants (PVs) identified in genes involved in the DNA homologous recombination repair (HRR) mechanism are the main cause of hereditary breast and ovarian cancer syndrome (HBOC). The main objective of this study was to identify differential plasma metabolomic profiles associated with the HRR genotype in healthy individuals.Cascade testing was performed by Sanger sequencing...

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Literature Corpus work: 4fcc5045-7711-581e-95b4-70b33dd50c05
DOI: 10.21203/rs.3.rs-7297956/v1

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