Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasma Metabolome Signature Indicative of BRCA1 Germline Status Independent of Cancer Incidence

7 Apr 2021

Abstract excerpt

Individuals carrying a pathogenic germline variant in the breast cancer predisposition gene BRCA1 (gBRCA1+) are prone to developing breast cancer. Apart from its well-known role in DNA repair, BRCA1 has been shown to powerfully impact cellular metabolism. While, in general, metabolic reprogramming was named a hallmark of cancer, disrupted metabolism has also been suggested to drive cancer cell evolution and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diet and metabolism studies
Share to Epigenetics and DNA Methylation
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33898308
DOI: 10.3389/fonc.2021.627217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasma Metabolome Signature Indicative of BRCA1 Germline Status Independent of Cancer IncidencePMID 33898308Read ↗

A joint analysis of metabolomics and genetics of breast cancer.Semantic proximity Read ↗

Correlation between metabolic characteristics and breast cancer subtypes and prognosisSemantic proximity Read ↗

Metabolomics-enabled biomarker discovery in breast cancer researchSemantic proximity Read ↗

Proteogenomic Metabolism Dependent Signature Identifies Worse Outcome in Breast And Other CancersSemantic proximity Read ↗

Germline BAP1 mutations induce a Warburg effect.Semantic proximity Read ↗

Metabolomics reveals novel blood plasma biomarkers associated to the BRCA1-mutated phenotype of human breast cancer.Semantic proximity Read ↗

Metabolomic-driven prediction of the mutational status of healthy individuals with a family history of hereditary breast and ovarian cancer syndrome: the HRRmet study.Semantic proximity Read ↗

Immunometabolism characteristics and a potential prognostic risk model associated with TP53 mutations in breast cancer.Semantic proximity Read ↗

Metabolomic-driven prediction of the mutational status of healthy individuals with a family history of hereditary breast and ovarian cancer syndrome: The HRRmet studySemantic proximity Read ↗

Circulating amino acids, amino acid metabolites, dipeptides, and other cationic metabolites and risk of breast cancerSemantic proximity Read ↗

Metabolomics in breast cancer: A decade in review.Semantic proximity Read ↗

Correlated metabolomic, genomic, and histologic phenotypes in histologically normal breast tissue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.