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Metabolomics reveals novel blood plasma biomarkers associated to the BRCA1-mutated phenotype of human breast cancer.

Scientific reports - 19 Dec 2017

Roig Bàrbara, Rodríguez-Balada Marta, Samino Sara, Lam Eric W-F, Guaita-Esteruelas Sandra, Gomes Ana R, Correig Xavier, Borràs Joan, Yanes Oscar, Gumà Josep

Abstract excerpt

Hereditary breast and ovarian cancer syndrome (HBOC) is partly due to the presence of mutations in the BRCA genes. Triple-negative (TN) breast cancer (BC) shares histological characteristics with germline BRCA1 mutation-associated tumours. We have investigated the metabolic profiles of human breast cancer (BC) cell lines carrying BRCA1 pathogenic mutations by non-targeted liquid chromatography coupled to mass...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29259228
DOI: 10.1038/s41598-017-17897-8
PMCID: PMC5736621

Genes

BRCA1

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