Article
Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities.
Nature cancer - 1 Apr 2024
Jiang Yi-Zhou, Ma Ding, Jin Xi, Xiao Yi, Yu Ying, Shi Jinxiu, Zhou Yi-Fan, Fu Tong, Lin Cai-Jin, Dai Lei-Jie, Liu Cheng-Lin, Zhao Shen, Su Guan-Hua, Hou Wanwan, Liu Yaqing, Chen Qingwang, Yang Jingcheng, Zhang Naixin, Zhang Wen-Juan, Liu Wei, Ge Weigang, Yang Wen-Tao, You Chao, Gu Yajia, Kaklamani Virginia, Bertucci François, Verschraegen Claire, Daemen Anneleen, Shah Nakul M, Wang Ting, Guo Tiannan, Shi Leming, Perou Charles M, Zheng Yuanting, Huang Wei, Shao Zhi-Ming
Abstract excerpt
Molecular profiling guides precision treatment of breast cancer; however, Asian patients are underrepresented in publicly available large-scale studies. We established a comprehensive multiomics cohort of 773 Chinese patients with breast cancer and systematically analyzed their genomic, transcriptomic, proteomic, metabolomic, radiomic and digital pathology characteristics. Here we show that compared to breast...
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