Article

Genomic basis of developmental defects of enamel and sex-specific effects

2026-07-10

Abstract excerpt

We conducted a multi-ancestry genome-wide association study (GWAS) of developmental defects of enamel (DDE) in the primary dentition among 6,061 U.S. preschool-aged children (3–5 years). We investigated four DDE phenotypes (demarcated opacities, diffuse opacities, hypoplastic defects, and a combined DDE trait) leveraging main-effect models, joint gene-sex interaction testing (2df), and sex-stratified analyses. SNP...

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Literature Corpus work: ae3b8b20-db6f-584e-a61b-33958b1b178f
DOI: 10.64898/2026.07.06.26355672

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