Integrative analysis of transcriptome dynamics during human craniofacial development identifies candidate disease genes.

Abstract excerpt

Craniofacial disorders arise in early pregnancy and are one of the most common congenital defects. To fully understand how craniofacial disorders arise, it is essential to characterize gene expression during the patterning of the craniofacial region. To address this, we performed bulk and single-cell RNA-seq on human craniofacial tissue from 4-8 weeks post conception. Comparisons to dozens of other human tissues...

Topics

• Pregnancy
• Female
• Humans
• Transcriptome
• Bone and Bones
• Mutation