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Article

Tooth agenesis: What do we know and is there a connection to cancer?

Clinical genetics - 1 Apr 2021

Bonczek Ondrej, Krejci Premysl, Izakovicova-Holla Lydie, Cernochova Pavlina, Kiss Igor, Vojtesek Borivoj

Abstract excerpt

Like all developmental processes, odontogenesis is highly complex and dynamically regulated, with hundreds of genes co-expressed in reciprocal networks. Tooth agenesis (missing one or more/all teeth) is a common human craniofacial anomaly and may be caused by genetic variations and/or environmental factors. Variants in PAX9, MSX1, AXIN2, EDA, EDAR, and WNT10A genes are associated with tooth agenesis. Currently,...

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PMID: 33249565
DOI: 10.1111/cge.13892

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