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Suppression of the necroptotic cell death pathways improves survival in Smn2B/− mice

3 Aug 2022

Abstract excerpt

Spinal muscular atrophy (SMA) is a monogenic neuromuscular disease caused by low levels of the Survival Motor Neuron (SMN) protein. Motor neuron degeneration is the central hallmark of the disease. However, the SMN protein is ubiquitously expressed and depletion of the protein in peripheral tissues results in intrinsic disease manifestations, including muscle defects, independent of neurodegeneration. The...

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PMID: 35990890
DOI: 10.3389/fncel.2022.972029

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