Article

Coexisting morpho-biotypes unveil the regulatory bases of phenotypic plasticity in pancreatic ductal adenocarcinoma

2022-12-12

Abstract excerpt

Intratumor morphological heterogeneity predicts clinical outcomes of pancreatic ductal adenocarcinoma (PDAC). However, it is only partially understood at the molecular level and devoid of clinical actionability. In this study we set out to determine the gene regulatory networks and expression programs underpinning intra-tumor morphological variation in PDAC. To this aim, we identified and deconvoluted at single ce...

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Literature Corpus work: 4f31b675-7c19-5b8a-8f6f-f0043514e2de
DOI: 10.1101/2022.12.12.520054

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