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Multi-omics integration of DNA polymerase epsilon protein family reveals clinical outcomes and functional signatures in hepatocellular carcinoma

2022-09-22

Abstract excerpt

BACKGROUND Numerous genetic sequencing projects have demonstrated that alterations in Polε (DNA polymerase epsilon ) due to various causes are associated with the development of multiple human cancers. However, the biological functions of its four core genes, POLE1/2/3/4/, in the occurrence, progression, and prognosis of hepatocellular carcinoma(HCC) remain poorly understood to date. METHODS Multi-omics, multi-l...

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Literature Corpus work
262151de-039b-54cc-b4c8-a6340033adc2
DOI
10.21203/rs.3.rs-2038235/v1
Open publication

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Multi-omics integration of DNA polymerase epsilon protein family reveals clinical outcomes and functional signatures in hepatocellular carcinomaDOI 10.21203/rs.3.rs-2038235/v1
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