Article

Respiration enhances TDP-43 toxicity, but TDP-43 retains some toxicity in the absence of respiration

2018-09-13

Abstract excerpt

The trans-activating response DNA-binding protein 43 (TDP-43) is a transcriptional repressor and splicing factor. TDP-43 is normally mostly in the nucleus, although it shuttles to the cytoplasm. Mutations in TDP-43 are one cause of familial amyotrophic lateral sclerosis (ALS). In neurons of these patients, TDP-43 forms cytoplasmic aggregates. In addition, wild-type TDP-43 is also frequently found in neuronal cytop...

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Literature Corpus work: 4ed7320c-4ab5-51f1-8eac-a2e5f32aa118
DOI: 10.1101/415893

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