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Article

Differential toxicity of TAR DNA-binding protein 43 isoforms depends on their submitochondrial localization in neuronal cells.

Journal of neurochemistry - 1 Sept 2018

Salvatori Illari, Ferri Alberto, Scaricamazza Silvia, Giovannelli Ilaria, Serrano Alessia, Rossi Simona, D'Ambrosi Nadia, Cozzolino Mauro, Giulio Andrea Di, Moreno Sandra, Valle Cristiana, Carrì Maria Teresa

Abstract excerpt

TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein and a major component of protein aggregates found in amyotrophic lateral sclerosis and several other neurodegenerative diseases. TDP-43 exists as a full-length protein and as two shorter forms of 25 and 35 kDa. Full-length mutant TDP-43s found in amyotrophic lateral sclerosis patients re-localize from the nucleus to the cytoplasm and in part to...

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PMID: 29779213
DOI: 10.1111/jnc.14465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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