Article

Hyperactive end joining repair mediates resistance to DNA damaging therapy in p53-deficient cells

2020-04-03

Abstract excerpt

TP53 mutations in cancer are associated with poor patient outcomes and resistance to DNA damaging therapies 1–3 . However, the mechanisms underlying treatment resistance in p53-deficient cells remain poorly characterized. Here, we show that p53-deficient cells exhibit hyperactive repair of therapy-induced DNA double strand breaks (DSBs), which is suppressed by inhibition of DNA-dependent protein kinase (DNA-PK)....

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Literature Corpus work: 4ec0d8cf-fdd8-5173-ac77-ceff7b001001
DOI: 10.1101/2020.04.01.021253

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